Two pretty American girls on a road trip across Europe end up alone in the woods at night when their car breaks down in rural Germany. As they search for help they find an isolated house. Offering to call them a taxi, the houses owner Dr. Heiter, a retired surgeon, invites the girls inside with the promise of a drink and dry place to wait for help to arrive. Too late they realise that there is something not quite right about the formidable Dr. Heiter... As their demented host explains his twisted vision, the two girls discover that they are soon to become a lot closer to each other than they ever wanted to be. Heiter's plan is to connect the two girls, along with a third person, a hapless Japanese tourist, to each other via their gastric systems in a daring bid to be the first person to create a Siamese triplet bringing to life his sick lifetime fantasy "The Human Centipede". Inspired by a conversation over what punishment would be appropriate for convicted paedophiles, Tom Six's bizarre biological horror film has the distinction of being 100% medically accurate.