Goodbye Charlie begins with a humorous opening sequence, in which Charles Sorel is an inveterate philanderer practicing his wily crafts on women aboard an ocean liner. He is found out by a jealous husband and shot dead, falling overboard into the sea. Through a celestial fluke, Charles' soul enters the well-rounded body of a woman who renames herself Charlie. In this form, Charlie seeks to settle old scores with her murderer as well as several other enemies. As if these complications aren't enough, Charlie's best friend, George Tracy, falls in love with Charlie, knowing full well that she isn't really who she claims to be.